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KMID : 0377519850100010051
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Chung-Ang Journal of Medicine
1985 Volume.10 No. 1 p.51 ~ p.58
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Effects of Vanadate on the Myocardial Contractility and Action Potential of Rabbit Pabillary Muscles
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Abstract
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Rabbit papillary muscle preparations were used to investigate the effects of vanadate on isometric contractility and variabilities of action potential.
To record the myocardial contractility and action potential of rabbit papillary muscles, 31NI KCI-filled glass microelectrodes were directly introduced into the muscle cells.
The following results were obtained:
1. By increase of concentration of vanadate, myocardial isometric contractility increased but action potential did not change.
2. In case of preparation with the calcium antagonist(Diltiazem) myocardial contractility decreased and the overshoot potential and APD50 also decreased.
3. In case of preparations simultaneously with vanadate and Diltianzem, the effect in case of initial
treatment with vanadate was completely reversed ay later treatment with Diltiazem.
Above results could be interpreted as that the inflow of calcium ion was increased at the myocardial cell
membrane level and then the myocardial contractility was increased by vanadate.
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